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| ||REQUEST TO REMOVETOP1 inhibition therapy protects against SARS-CoV-2-induced ...|
Here, using multidimensional epigenetic, transcriptional, in vitro, and in vivo analyses, we report that topoisomerase 1 (TOP1) inhibition suppresses lethal inflammation induced by SARS-CoV-2. Therapeutic treatment with two doses of topotecan (TPT), an FDA-approved TOP1 inhibitor, suppresses infection-induced inflammation in hamsters.
| ||REQUEST TO REMOVETop1- and Top2-mediated topological transitions at ...|
TOP1 ablation does not affect fork progression and stability and does not cause activation of the Rad53 checkpoint kinase. top2 mutants accumulate sister chromatid junctions in S phase without affecting fork progression and activate Rad53 at the M-G1 transition. top1 top2 double mutants exhibit fork block and processing and phosphorylation of ...
| ||REQUEST TO REMOVETOP1 | SGD|
The Top1 protein, like other type IB topoisomerases, relaxes supercoiled DNA by forming a DNA-enzyme complex and transiently cleaving one strand via a nucleophilic attack that results in a covalent linkage with the 3' end of the cleaved strand. The 5' end can then rotate freely ( 7 ).
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| ||REQUEST TO REMOVETOP1 - DNA topoisomerase 1 - Homo sapiens (Human) - TOP1 gene ...|
TOP1. 204. Annotation score: Annotation score:1 out of 5. The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score cannot be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.
| ||REQUEST TO REMOVETopoisomerase I Antibody (CPTC-TOP1-1) - DSHB|
CPTC-TOP1-1 was deposited to the DSHB by Clinical Proteomics Technologies for Cancer (DSHB Hybridoma Product CPTC-TOP1-1) Storage and Handling Recommendations Although many cell products are maintained at 4°C for years without loss of activity, shelf-life at 4°C is highly variable.
| ||REQUEST TO REMOVEMorphine-pathway block in top1 poppies | Nature|
Sep 22, 2004 · The top1 mutant is not only contributing to the genetic dissection of the morphine pathway, it has been swiftly deployed for an agriculturally viable supply of thebaine and is a crop that carries ...
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| ||REQUEST TO REMOVETOP1-T Front Top Plate Spacer Kit - Toytec Lifts|
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| ||REQUEST TO REMOVETOP1 - DNA topoisomerase 1 - Candida albicans (Yeast) - TOP1 ...|
top1_canax <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries.
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| ||REQUEST TO REMOVETOP1 Gene - GeneCards | TOP1 Protein | TOP1 Antibody|
TOP1 (DNA Topoisomerase I) is a Protein Coding gene. Diseases associated with TOP1 include Systemic Scleroderma and Neutropenia . Among its related pathways are Metabolism of proteins and DNA Damage . Gene Ontology (GO) annotations related to this gene include core promoter sequence-specific DNA binding .
| ||REQUEST TO REMOVERecombinant Human TOP1 Protein, Baculovirus-Insect Cells, His ...|
Recombinant Human TOP1 Protein (Met1-Phe765) 17455-H07B with a fusion His Tag, is expressed in Baculovirus-Insect Cells. With high purity, high biological activity, high stability, and other superior features, you can use this Human TOP1 protein for relevant bioassay and related research.
| ||REQUEST TO REMOVETOP1 DNA topoisomerase I [ (human)] - National Institutes of ...|
TOP1 differentially modulates R-loops across the human genome. Results from a study on gene expression variability markers in early-stage human embryos shows that TOP1 is a putative expression variability marker for the 3-day, 8-cell embryo stage. High TOP1 expression is associated with aggressive tumor phenotype in breast cancer.
| ||REQUEST TO REMOVE854156 - Gene ResultTOP1 DNA topoisomerase 1 |
Nov 17, 2020 · top1 mutants had greatly elevated levels of instability within the tandemly-repeated ribosomal RNA genes. Top1 is a critical factor in suppression of instability associated with potential G4 DNA-forming sequences. analysis of how human and yeast DNA topoisomerase I domain interactions impact enzyme activity and sensitivity to camptothecin
| ||REQUEST TO REMOVETop1 - Revista ta de Lifestyle|
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| ||REQUEST TO REMOVETOP1 - Wikipedia|
The briefly attached, covalently bonded TOP1-DNA structure at the 3' end of a cleaved DNA single strand is called a TOP1-DNA cleavage complex, or TOP1cc. The TOP1cc is a specific target of TOP1 inhibitors. One of the first inhibitors shown to target TOP1 is irinotecan.
| ||REQUEST TO REMOVETOP1GAME遊戲|
| ||REQUEST TO REMOVETOP1 Antibody | Cell Signaling Technology|
TOP1 Antibody recognizes endogenous levels of total TOP1 protein. Species Reactivity: Human, Mouse, Rat. Source / Purification. Polyclonal antibodies are produced by ...
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